In this review:
- POSITIVE: updated 5-year results
- monarchE: updated results of adjuvant abemaciclib + endocrine therapy in HR+, HER2–, high-risk early breast cancer
- NATALEE: 5-year outcomes of ribociclib + NSAI in stage I/III, HR+, HER2− early breast cancer
- OptiTROP-Breast02: sac-TMT in pre-treated, advanced, HR+, HER2– breast cancer
- evERA BD: second-line giredestrant + everolimus in ER+, HER2– advanced breast cancer
- VIKTORIA-1: second-line gedatolisib + fulvestrant ± palbociclib in HR+, HER2–, PIK3CA wild-type advanced breast cancer
- DESTINY-Breast11: neoadjuvant T-DXd-THP versus SOC for high-risk, HER2+ early breast cancer
- DESTINY-Breast05: post-neoadjuvant T-DXd vs. T-DM1 in high-risk, HER2+ early breast cancer
- ASCENT-03: sacituzumab govitecan (SG) in advanced TNBC ineligible for PD-(L)1 inhibitors
- TROPION-Breast02: Dato-DXd vs. chemotherapy in metastatic TNBC ineligible for immunotherapy
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